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Skin boosters or polynucleotides – what is the difference?

Neither treatment changes volume or contour. This is about skin quality – moisture, elasticity, radiance. The difference lies in how they achieve it.

Two different routes

Skin boosters deliver hyaluronic acid into the skin. They act as a moisture reservoir: the skin binds more water and therefore appears plumper and smoother. The effect is noticeable comparatively quickly.

Polynucleotides fill nothing. They encourage the cells to work more actively again – the skin improves its quality through its own effort. This takes longer, but is regenerative rather than volumising.

When is which treatment appropriate?

Skin boosters are usually the first choice for dry, crêpey skin on the face, neck or décolleté, and when a visible freshening effect is wanted within a manageable timeframe.

Polynucleotides are particularly suited to thin, weakened skin and to the delicate eye area, where classic fillers are often not the right choice. They are also a good option for skin that has had a lot of sun exposure over the years.

Compared

Skin boostersPolynucleotides
How it worksmoisture reservoircell regeneration
Result visible2–4 weeks3–6 weeks
Longevity6–9 months6–9 months
Sessionsusually 2usually 2–3
Eye arealimitedparticularly suitable

Can they be combined?

Yes. The two approaches complement each other well: polynucleotides improve the foundation, skin boosters provide moisture. In practice I combine them regularly – adapted to the condition of the skin and the available timeframe.

Dr. Anna Kovács
Written and medically reviewed by Dr. Anna KovácsPhysician for general medicine · Aesthetic treatmentsLast updated: August 2026
This article provides general information and does not replace a personal medical consultation.
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