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Botox or hyaluronic acid – what is the difference?

This is the most common question in my practice – and a fair one, since both treatments are injected and both are known as „wrinkle treatments“. They work in completely different ways, however.

The essential difference

Botulinum toxin relaxes muscles. It is used where lines are caused by movement – when frowning, smiling or squinting. The muscle works less strongly and the skin above it smooths out.

Hyaluronic acid fills. It replaces volume lost over the years and cushions folds that remain visible even when the face is at rest. It can also shape contours – at the chin, cheek or lips.

How do you know which one you need?

A simple test: stand in front of the mirror and relax your face completely. Lines that then disappear are caused by movement – botulinum toxin helps here. Lines that remain visible at rest are static – hyaluronic acid is the more suitable choice.

Typically movement-related: frown lines, forehead lines, crow's feet. Typically static: the nasolabial fold, marionette lines, hollow cheeks.

Longevity and procedure compared

Botulinum toxinHyaluronic acid
How it worksrelaxes the musclereplaces volume
Result visibleafter 3–5 daysimmediately
Longevity3–4 months9–18 months
Reversibleno, wears off on its ownyes, with hyaluronidase
Duration15–20 minutes30–45 minutes

Can the two be combined?

Yes, and in practice this often makes sense. A typical example: botulinum toxin for the frown line, hyaluronic acid for the nasolabial fold. The two treatments do not interfere with each other and can be carried out in the same session.

What makes sense in your case is something we decide after analysing your face during the consultation – and sometimes the answer is that neither is needed for now.

Dr. Anna Kovács
Written and medically reviewed by Dr. Anna KovácsPhysician for general medicine · Aesthetic treatmentsLast updated: August 2026
This article provides general information and does not replace a personal medical consultation.
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